发给老马备查:
+ P0 t/ P9 l2 A6 h8 e滴水察海(69304838) 15:23:23% M2 i/ o0 ?3 V7 S* K/ o
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
, q6 D* @' E3 Z, U7 @. F( h吉非替尼和S-1连用的依据
! l \# m5 F# C3 ]- ^Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
, ?9 U3 m& V) l1 `' F3 y5 z是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达) I3 ?# \8 }/ b# |2 C2 f- ^+ u
这样是不是推理出,耐药后,可以用S-1和培美了?
* E# H7 A' |: T4 F$ a& E. A3 b5 t1 r结论:
' e4 s: [/ b( R如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |